The paper describes an original method for one-stage repair of combined through-and-through defect of soft tissues of the cheek, mouth angles, upper and lower lip. Russian Federation’s patent for invention No. 2489096 was granted for this method. We propose to use 3 different flaps cut from different anatomic areas, which have varying histological structures and independent blood supply. The important characteristic of our procedure is that the replacement flaps perform various functions. The ultimate result is to ensure the functional and anatomic adequacy of resected tissues (resultant through-and-through defect of the cheek, mouth angles, and upper and lower lip fragments), to improve the blood supply of used flaps, to reduce the time of patient rehabilitation, to decrease surgical traumaticity. The method is easy-to-use.

Different variants of the ectopic thyroid are rarely encountered in routine clinical practice and associated with a defect in thyroid embryo-genesis at its early stages. The symptoms depend on the site and sizes of the ectopic thyroid, its function and morphological structure. Its diagnosis is based on radiologic studies. Hormone suppression, radioiodine ablation, and surgery are treatment choices.

Head and neck cancers, including thyroid carcinomas, are characterized by high risk of metastasizing in regional lymph nodes. Lymph nodes status determines treatment of thyroid cancer as well as disease prognosis. Excision of affected lymph nodes is associated with risk reduction of relapse and reduction of mortality. However surgical treatment can be associated with some difficulties. Due to technologic progress modern ultrasonographs offer the possibility to visualize minimal tumor nodes (5–10 mm), which are characterized with complexity of localization during surgical manipulation, particularly in patients with relapses, that previously passed treatment (surgery and/or radiation therapy). These lymph nodes can be missed during surgical treatment, which will lead to reduction of treatment efficacy. The paper details utility of intraoperative ultrasound investigation as a method of obtaining information about localization of nonpalpable tumor nodes, cancer extension, reduction the possibility of non-radical surgical treatment and unnecessary extension of surgical treatment in patients with thyroid cancers, characterized with regional lymph nodes involvement.

The paper describes the first experience with the fibrin sealant Tissucol at Moscow City Cancer Hospital Sixty-Two. The authors used this agent in different clinical situations. However, Tissucol showed the highest efficacy in arresting long-term severe lymphorrhea. The described clinical case clearly demonstrates the abilities of this agent and allows it to be recommended for use in other areas of oncology.

MEN 2B syndrome is a subtype of the multiple endocrine neoplasia type 2. It is characterized by the development of aggressive forms of medullary thyroid cancer at an early age, pheochromocytoma and hyperparathyroid syndrome. This article provides an own clinical observation of the patient with MEN 2B syndrome associated with a mutation in the proto-oncogene RET.

Thyroid cancer metastasis to the brain is rare and little-studied pathology. Problems of their diagnosis and treatment remain to be solved. Features of this group is a metastatic lesion of the brain and bones of the cranial vault with extra- and intracranial growth. The paper details the clinical picture, X-ray, morphological diagnosis and treatment of patients with intracranial metastases thyroid cancer.

The paper describes a rare case of maxillary sinus metastasis of renal cell carcinoma in a 50-year-old man 7 years after nephrectomy. The tumor appeared as bleeding leading to anemia. The diagnostic difficulties associated with differences in X-ray and biopsy morphological data are considered. A correct diagnosis could be established during planned histological examination of the removed tumor. Adjuvant immunotherapy was performed. Examination following 8 postoperative months revealed no signs of progressive disease. The authors give a literature review.