Vol 5, No 4 (2015)

Cover Page

Full Issue

Editor’s note

EDITORIAL

Editorial A.

Abstract

Мы рады сообщить Вам, что научно-практический рецензируемый журнал «Опухоли головы и шеи» (http://ogsh.abvpress.ru / jour) с 14 декабря 2015 г. включен в новый перечень рецензируемых научных изданий Высшей аттестационной комиссии Министерства образования и науки.

Head and Neck Tumors. 2015;5(4):10
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DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORS

Diagnostic features of lung metastases differentiated thyroid cancer

Geliashvili T.M., Vazhenin A.V., Vasil’eva E.B., Afanas’eva N.G.

Abstract

Head and Neck Tumors. 2015;5(4):11-15
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Analysis of the impact of radiotherapy on long-term treatment results in patients with malignant salivary gland tumors

Vayradyan V.T., Mudunov A.M., Azizyan R.I., Zaderenko I.A., Alieva S.B., Rurua N.V., Kondrat’eva T.T., Ermilova V.D.

Abstract

Objective: to investigate the efficiency of radiotherapy for malignant salivary gland tumors and to reveal prognostic factors influencing overall and relapse-free survival rates in this patient group.

Materials and methods. The retrospective and prospective data of 111 patients with malignant salivary gland tumors were analyzed. All the examinees received preoperative radiotherapy to the primary focus and, if need be, regional metastatic areas; the cumulative focal dose was 40–65 (56.0 ± 8.9) Gy. In the following step, the patients were surgically treated. They were divided into 2 groups according to the degree of therapeutic pathomorphism: 1) Degree 0–III (91.9 %) and 2) Degree IV (8.1 %).

Results. Five- and ten-year overall survival rates were 60.1 ± 5.1 and 50.4 ± 5.7 % and 7.5 ± 11,69 and 87.5 ± 11.69 % (unachieved median) in Groups 1 and 2, respectively (p = 0.04); relapse-free survival rates were 53.6 ± 5.1 and 41.33 ± 5.5 % in Group 1 and 88.8 ± 10.4 and 88.8 ± 10.4 % in Group 2 (unachieved median) (р = 0.015). Cox multivariate regression analysis showed that the significant independent signs for overall survival were the pathomorphological characteristics of a tumor (risk ratio (RR) = 1.933; p = 0.010), process location (RR = 0.705; р = 0.010), and tumor grade (RR = 1.825; р = 0.010); those for relapse-free survival were the pathomorphological characteristics of a tumor (RR = 2.177; р = 0.001), regional lymph node metastases (RR = 1.543; р = 0.013), tumor localization (RR = 0.700; р = 0.014), effect of radiotherapy (RR = 1.767; р = 0.042), and tumor grade (RR = 1.754; р = 0.005).

Head and Neck Tumors. 2015;5(4):16-27
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ORIGINAL REPORT

Prognostic significance of clinical, morphological and molecular-genetic characteristics of larynx cancer, medic rehabilitation, quantitative estimation of the functional impairments extent for the purposes of expert-rehabilitative diagnostics

Shakhsuvaryan S.B., Polyakov B.I., Lomaya M.A.

Abstract

There have been presented a morphological classification and TNM international classification of a larynx cancer, distribution of malignant neoplasms of a given localization by stages considering the TNM parameters. There has been given a clinical characteristic of the disease depending on the process localization. There have been described the peculiarities of diagnostics and treatment as well as clinical, morphological and molecular-genetic prognostic factors. The main tasks and possibilities of medical rehabilitation of a given patients’ contingent have been shown including preservation of the larynx functions by means of reconstructive-restorative operations and the methods of the voice functions restoration after laryngectomia performing as well. There have been established the criteria of the functional impairments manifestation extent evaluation and there has been given stage-by-stage assessment of an extent of the body functions impairment in the larynx cancer in percent.
Head and Neck Tumors. 2015;5(4):28-40
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LITERATURE REVIEW

Brachytherapy in thetreatment of the oral and oropharyngeal cancer

Zhumankulov A.M., Ostrinskaya T.V., Litvinov A.P., Lebedeva Z.S.

Abstract

Background. One of the methods of radiotherapy of malignant tumors of oral cavity and oropharyngeal region today is interstitial radiation therapy – brachytherapy, allowing you to create the optimum dose of irradiation to the tumor, necessary for its destruction, without severe radiation reactions in the surrounding tissues unchanged. Brachytherapy has the following advantages: high precision – the ability of the local summarization of high single doses in a limited volume of tissue; good tolerability; a short time of treatment. At this time, brachytherapy is the method of choice used as palliative therapy and as a component of radical treatment.

Objective: The purpose of this article is a literature review about the latest achievements of interstitial brachytherapy in malignant tumors of the oral cavity and oropharynx.

Head and Neck Tumors. 2015;5(4):41-47
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Clinical features of the head and neck mucosal melanoma. А review

Ignatova A.V., Mudunov A.M., Podvyaznikov S.O.

Abstract

Melanoma is an aggressive and rare neoplasm of melanocytic origin. Mucosal melanomas of the head and neck account for 1 % of neoplasms, 0,2–8,0 4 % of all melanomas and over 50 % of all mucosal melanomas. To date, in Russian and foreign literature only few retrospective series and case reports have been reported on mucosal melanoma. Despite melanoma’s common histological origin, head and neck mucosal melanoma presentation has some specific features due to its anatomical localization and poor clinical outcomes compared with those of cutaneous melanomas. Mucosal melanoma has a high metastatic potential. Five-year overall survival does not exceed 30 %. Advances in understanding of the clinical presentation can be used for prediction of behaviour and prognosis of this disease. We considered and analised articles devoted to clinical features of head and neck mucosal melanoma according to its localization.
Head and Neck Tumors. 2015;5(4):48-52
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CASE REPORT

Locally advanced thyroid cancer: case report

Azizyan R.I., Saprina O.A., Bekyashev A.K., Belov D.S., Gasparyan T.G., Gorobets E.S., Balandin V.V., Ungiadze G.V., Dronova E.L., Vasil’ev A.V., Lomaya M.V.

Abstract

The paper gives the results of treatment in a female patient with locally advanced thyroid cancer with a tumor thrombus in the internal jugular vein with laryngeal or tracheal involvement, and a giant metastasis into the bone of the vault of the skull.
Head and Neck Tumors. 2015;5(4):53-57
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OBITUARY

Памяти Владимира Олеговича Ольшанского

Editorial A.

Abstract

11 сентября 2015 г. после продолжительной болезни ушел из жизни доктор медицинских наук, профессор В.О. Ольшанский, один из ведущих специалистов в области опухолей головы и шеи.
Head and Neck Tumors. 2015;5(4):58
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Памяти Роберта Ивановича Вагнера

Editorial A.

Abstract

16 ноября 2015 г., на 91-м году, ушел из жизни Роберт Иванович Вагнер – известный онколог, главный научный сотрудник ФГБУ «Научно-исследовательский институт онкологии им. Н.Н. Петрова» Минздрава России, доктор медицинских наук, профессор, лауреат Государственной премии Российской Федерации, член-корреспондент Российской академии наук, заслуженный деятель науки Российской Федерации, член редколлегии журнала «Вопросы онкологии».
Head and Neck Tumors. 2015;5(4):59
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Некролог проф. Ольшанскому В.О.

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Abstract

По просьбе Сергея Олеговича высылаю текст заметки памяти прф. Ольшанского В.О., который планируется опубликовать в нашем журнале.
Head and Neck Tumors. 2015;5(4):
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