Vol 3, No 3 (2013)

The treatment of aggressive benign and malignant head and neck tumors requires partial (segmental) or half mandibular resection on frequent occasions. Mandibular defects of even a small extent lead to significant cosmetic deformity and are accompanied by impairment of important functions, such as chewing, swallowing, and correct speech production. Mandibuloplasty using a revascularized peroneal graft is the method of choice after extensive resections for disseminated benign and malignant tumors.

The literature review analyzes current trends in the treatment of oral mucosal cancer. Surgery performed at the first stage of complex or combination treatment, followed by radiation or platinum drug-based competitive chemotherapy, is the standard treatment. To choose treatment policy depends on the extent of a tumor process and the presence of unfavorable prognostic factors that determine the high risk of disease recurrence and progression. The basic principles of combination and complex therapy are to strictly comply with the time and sequence of therapy. The treatment of recurrent tumors to be surgically untreated is based on chemotherapy using platinum and target drugs.

Cerebral metastases cancer of the larynx are rare and poorly understood pathology, many questions of diagnostics and treatment of this pathology remain open. In the work presents clinical cases сerebral metastases cancer of the larynx. Special attention is paid to surgical treatment in complex with chemotherapy.