Vol 4, No 4 (2014)

Results of treating of 99 patients with differentiated thyroid cancer spreading beyond the capsule of the organ were analysed. In most cases with spreading the tumor to the tracheal rings performing of organ-preserving operations (from “window-like” tracheal resections to circular tracheal resection with intertracheal anastomosis) is possible. Choosing of type of operation to be performed depends on localisation and spread of tumor invasion of trachea, pharynx and esophagus. Using of combined operations in patients with locally-spread thyroid cancer allows to achieve long and stable remission in most of the cases.

The article represents a detailed technique of hiding mucosa defects in the retromolar area with temporal fascial and aponeurotic flap as applied to the surgical stage in the combined and complex treatment.

Advances in understanding of the molecular mechanisms underlying oral squamous cell carcinoma (OSCC) have resulted in an increasing number of molecules-biomarkers that can be used for prediction of behaviour of this disease to achieve the above objective.

We identified and classified 24 molecular biomarkers into five groups based on their biological functions: 1) cell cycle acceleration and proliferation; 2) hypoxia-inducible factors; 3) tumour suppression and apoptosis; 4) angiogenesis; 5) cell adhesion and matrix degradation. We considered articles published in PubMed-indexed journals over the past 8 years and conducted a literature review of studies examining the role of immunohistochemistry-based protein biomarkers in predicting OSCC outcome.

Study objective: development of the new method of reconstruction of upper section of the aerodigestive tract with the use of a microsurgical colonic-ileal autogenic graft that allows instant recovery of the food passage and voice function.

A clinical case of successful treatment of a patient with locally distributed hypopharynx cancer is provided, regarding which microsurgical reconstruction of upper sections of the aerodigestive tract was performed with a free colonic-ileal autogenic graft at the surgical stage of therapy after laryngectomy with sleeve resection of the hypopharynx.

The use of a colonic-ileal autogenic graft in the course of reconstruction of upper sections of the aerodigestive tract allowed instant recovery of both food passage and voice function for the patient after laryngectomy with sleeve resection of the hypopharynx.Conclusions:

1. Application of this autogenic graft as a plastic material allows recovering both food passage and voice function instantly and completely with circular defects of upper sections of the aerodigestive tract.

2. The ileocecal valve included into the structure of the combined autogenic graft prevents saliva and food aspiration into the trachea through the tracheo-oesophageal shunt.

3. Mucous secretion of the autogenic graft has no aggressive action on the mucous membrane of the trachea, which allows implementation of the vocal rehabilitation plan.

4. After the flap formation, there is no functional or aesthetic damage in the donor area.

5. This reconstruction method cuts down the rehabilitation time significantly as well as decreases the patient’s disability level.